Idiopathic inflammatory myopathies: pathogenic mechanisms of muscle weakness
نویسندگان
چکیده
منابع مشابه
Immune mechanisms in the pathogenesis of idiopathic inflammatory myopathies
Idiopathic inflammatory myopathies (IIMs), comprising polymyositis, dermatomyositis, and inclusion-body myositis, are characterized by inflammatory cell infiltrates in skeletal muscle tissue, muscle weakness, and muscle fatigue. The cellular infiltrates often consist of T lymphocytes and macrophages but also, in some cases, B lymphocytes. Emerging data have led to improved phenotypic characteri...
متن کاملRole of non-immune mechanisms of muscle damage in idiopathic inflammatory myopathies
Idiopathic inflammatory myopathies (IIMs) comprise a group of autoimmune diseases that are characterized by symmetrical skeletal muscle weakness and muscle inflammation with no known cause. Like other autoimmune diseases, IIMs are treated with either glucocorticoids or immunosuppressive drugs. However, many patients with an IIM are frequently resistant to immunosuppressive treatments, and there...
متن کاملClassification of Idiopathic Inflammatory Myopathies
15 DOI 10/1007/978-1-60327-827-0_2, © Humana Press. a part of Springer Science + Business Media, LLC 2009 Abstract Although it has been long recognized that inflammatory muscle disease of unknown etiology may present clinically and respond to therapy in a variety of ways, our approaches regarding how to best classify or divide these entities into more understandable groups of patients has evolv...
متن کاملTreatment of idiopathic inflammatory myopathies.
PURPOSE OF REVIEW This article reviews the results of recent therapeutic trials in dermatomyositis, polymyositis, and inclusion body myositis and suggests an approach to treating patients with inflammatory myopathy. RECENT FINDINGS We reviewed 10 double-blind, placebo-controlled therapeutic trials in patients with inflammatory myopathy. Only one, using intravenous immunoglobulin in refractory...
متن کاملPathogenic Mechanisms in Centronuclear Myopathies
Centronuclear myopathies (CNMs) are a genetically heterogeneous group of inherited neuromuscular disorders characterized by clinical features of a congenital myopathy and abundant central nuclei as the most prominent histopathological feature. The most common forms of congenital myopathies with central nuclei have been attributed to X-linked recessive mutations in the MTM1 gene encoding myotubu...
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ژورنال
عنوان ژورنال: Skeletal Muscle
سال: 2013
ISSN: 2044-5040
DOI: 10.1186/2044-5040-3-13